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miR-605 joins p53 network to form a p53:miR-605:Mdm2 positive feedback loop in response to stress
In cancers with wild-type (WT) p53 status, the function of p53 is inhibited through direct interaction with Mdm2 oncoprotein, a negative feedback loop to limit the function of p53. In response to cellular stress, p53 escapes the p53:Mdm2 negative feedback to accumulate rapidly to induce cell cycle a...
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| Glavni autori: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2011
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3034018/ https://ncbi.nlm.nih.gov/pubmed/21217645 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.347 |
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