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miR-605 joins p53 network to form a p53:miR-605:Mdm2 positive feedback loop in response to stress

In cancers with wild-type (WT) p53 status, the function of p53 is inhibited through direct interaction with Mdm2 oncoprotein, a negative feedback loop to limit the function of p53. In response to cellular stress, p53 escapes the p53:Mdm2 negative feedback to accumulate rapidly to induce cell cycle a...

詳細記述

保存先:
書誌詳細
主要な著者: Xiao, Jiening, Lin, Huixian, Luo, Xiaobin, Luo, Xiaoyan, Wang, Zhiguo
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3034018/
https://ncbi.nlm.nih.gov/pubmed/21217645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.347
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