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Optimal Inhibition of Choroidal Neovascularization by scAAV2 with VMD2 Promoter-driven Active Rap1a in the RPE

Age-related macular degeneration (AMD) is a multifactorial chronic disease that requires long term treatment. Gene therapy is being considered as a promising tool to treat AMD. We found that increased activation of Rap1a in the retinal pigment epithelium (RPE) reduces oxidative signaling to maintain...

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Wang, Haibo, Kunz, Eric, Stoddard, Gregory J., Hauswirth, William W., Hartnett, M. Elizabeth
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6823539/
https://ncbi.nlm.nih.gov/pubmed/31673119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-52163-z
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