Retinal pigment epithelial cell expression of active Rap 1a by scAAV2 inhibits choroidal neovascularization

To test the hypothesis that increased Rap1a activity specifically in retinal pigment epithelial cells resists choroidal neovascularization (CNV), self-complementary adeno-associated virus 2 (scAAV2) with RPE65-promoter-driven GFP vectors were generated and introduced subretinally into Rap1b-deficien...

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Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Wang, Haibo, Han, Xiaokun, Bretz, Colin A, Becker, Silke, Gambhir, Deeksha, Smith, George W, Samulski, R Jude, Wittchen, Erika S, Quilliam, Lawrence A, Chrzanowska-Wodnicka, Magdalena, Hartnett, M Elizabeth
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4996131/
https://ncbi.nlm.nih.gov/pubmed/27606349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2016.56
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