Rap1 GTPase Activation and Barrier Enhancement in RPE Inhibits Choroidal Neovascularization In Vivo

Loss of barrier integrity precedes the development of pathologies such as metastasis, inflammatory disorders, and blood-retinal barrier breakdown present in neovascular age-related macular degeneration. Rap1 GTPase is involved in regulating both endothelial and epithelial cell junctions; the specifi...

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Detalhes bibliográficos
Main Authors: Wittchen, Erika S., Nishimura, Eiichi, McCloskey, Manabu, Wang, Haibo, Quilliam, Lawrence A., Chrzanowska-Wodnicka, Magdalena, Hartnett, M. Elizabeth
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3769400/
https://ncbi.nlm.nih.gov/pubmed/24039860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0073070
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