Activation of Rap1 inhibits NADPH oxidase-dependent ROS generation in retinal pigment epithelium and reduces choroidal neovascularization

Activation of Rap1 GTPase can improve the integrity of the barrier of the retina pigment epithelium (RPE) and reduce choroidal neovascularization (CNV). Inhibition of NADPH oxidase activation also reduces CNV. We hypothesize that Rap1 inhibits NADPH oxidase-generated ROS and thereby reduces CNV form...

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Autors principals: Wang, Haibo, Jiang, Yanchao, Shi, Dallas, Quilliam, Lawrence A., Chrzanowska-Wodnicka, Magdalena, Wittchen, Erika S., Li, Dean Y., Hartnett, M. Elizabeth
Format: Artigo
Idioma:Inglês
Publicat: Federation of American Societies for Experimental Biology 2014
Matèries:
Research Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868836/
https://ncbi.nlm.nih.gov/pubmed/24043260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-240028
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