Activation of Rap1 inhibits NADPH oxidase-dependent ROS generation in retinal pigment epithelium and reduces choroidal neovascularization

Activation of Rap1 GTPase can improve the integrity of the barrier of the retina pigment epithelium (RPE) and reduce choroidal neovascularization (CNV). Inhibition of NADPH oxidase activation also reduces CNV. We hypothesize that Rap1 inhibits NADPH oxidase-generated ROS and thereby reduces CNV form...

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Hlavní autoři: Wang, Haibo, Jiang, Yanchao, Shi, Dallas, Quilliam, Lawrence A., Chrzanowska-Wodnicka, Magdalena, Wittchen, Erika S., Li, Dean Y., Hartnett, M. Elizabeth
Médium: Artigo
Jazyk:Inglês
Vydáno: Federation of American Societies for Experimental Biology 2014
Témata:
Research Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868836/
https://ncbi.nlm.nih.gov/pubmed/24043260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-240028
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