Active Rap1-mediated Inhibition of Choroidal Neovascularization Requires Interactions with IQGAP1 in Choroidal Endothelial Cells

Neovascular age-related macular degeneration (nAMD) is a leading cause of blindness. The pathophysiology involves activation of choroidal endothelial cells (CECs) to transmigrate the retinal pigment epithelial (RPE) monolayer and form choroidal neovascularization (CNV) in the neural retina. The mult...

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Udgivet i:FASEB J
Main Authors: Ramshekar, Aniket, Wang, Haibo, Kunz, Eric, Pappas, Christian, Hageman, Gregory S., Chaqour, Brahim, Sacks, David B., Hartnett, M. Elizabeth
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8238370/
https://ncbi.nlm.nih.gov/pubmed/34166557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.202100112R
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