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Roles of monocarboxylate transporter subtypes in promotion and suppression of osteoclast differentiation and survival on bone

Monocarboxylate transporters (MCTs) provide transmembrane transport of monocarboxylates such as lactate and pyruvate. The present results showed that α-cyano-4-hydroxycinnamic acid (CHC), an inhibitor of MCTs, promoted osteoclast differentiation from macrophages at lower concentrations (0.1–0.3 mM)...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Imai, Hiroko, Yoshimura, Kentaro, Miyamoto, Yoichi, Sasa, Kiyohito, Sugano, Marika, Chatani, Masahiro, Takami, Masamichi, Yamamoto, Matsuo, Kamijo, Ryutaro
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6821745/
https://ncbi.nlm.nih.gov/pubmed/31666601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-52128-2
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