Monocarboxylate transporter-1 promotes osteoblast differentiation via suppression of p53, a negative regulator of osteoblast differentiation

Monocarboxylate transporter-1 (MCT-1) is a transmembrane transporter for monocarboxylates including lactate and pyruvate. Silencing Mct1 by its small interfering RNA (siRNA) suppressed the expression of marker genes for osteoblast differentiation, namely, Tnap, Runx2, and Sp7, induced by BMP-2 in mo...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Sasa, Kiyohito, Yoshimura, Kentaro, Yamada, Atsushi, Suzuki, Dai, Miyamoto, Yoichi, Imai, Hiroko, Nagayama, Kazuhiro, Maki, Koutaro, Yamamoto, Matsuo, Kamijo, Ryutaro
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6043614/
https://ncbi.nlm.nih.gov/pubmed/30002387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-28605-5
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge