Monocarboxylate transporter-1 promotes osteoblast differentiation via suppression of p53, a negative regulator of osteoblast differentiation

Monocarboxylate transporter-1 (MCT-1) is a transmembrane transporter for monocarboxylates including lactate and pyruvate. Silencing Mct1 by its small interfering RNA (siRNA) suppressed the expression of marker genes for osteoblast differentiation, namely, Tnap, Runx2, and Sp7, induced by BMP-2 in mo...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Sasa, Kiyohito, Yoshimura, Kentaro, Yamada, Atsushi, Suzuki, Dai, Miyamoto, Yoichi, Imai, Hiroko, Nagayama, Kazuhiro, Maki, Koutaro, Yamamoto, Matsuo, Kamijo, Ryutaro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6043614/
https://ncbi.nlm.nih.gov/pubmed/30002387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-28605-5
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