Roles of monocarboxylate transporter subtypes in promotion and suppression of osteoclast differentiation and survival on bone

Monocarboxylate transporters (MCTs) provide transmembrane transport of monocarboxylates such as lactate and pyruvate. The present results showed that α-cyano-4-hydroxycinnamic acid (CHC), an inhibitor of MCTs, promoted osteoclast differentiation from macrophages at lower concentrations (0.1–0.3 mM)...

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Published in:Sci Rep
Main Authors: Imai, Hiroko, Yoshimura, Kentaro, Miyamoto, Yoichi, Sasa, Kiyohito, Sugano, Marika, Chatani, Masahiro, Takami, Masamichi, Yamamoto, Matsuo, Kamijo, Ryutaro
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6821745/
https://ncbi.nlm.nih.gov/pubmed/31666601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-52128-2
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