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Roles of monocarboxylate transporter subtypes in promotion and suppression of osteoclast differentiation and survival on bone

Monocarboxylate transporters (MCTs) provide transmembrane transport of monocarboxylates such as lactate and pyruvate. The present results showed that α-cyano-4-hydroxycinnamic acid (CHC), an inhibitor of MCTs, promoted osteoclast differentiation from macrophages at lower concentrations (0.1–0.3 mM)...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Imai, Hiroko, Yoshimura, Kentaro, Miyamoto, Yoichi, Sasa, Kiyohito, Sugano, Marika, Chatani, Masahiro, Takami, Masamichi, Yamamoto, Matsuo, Kamijo, Ryutaro
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6821745/
https://ncbi.nlm.nih.gov/pubmed/31666601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-52128-2
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