Inflammatory cytokines and organ dysfunction associate with the aberrant DNA methylome of monocytes in sepsis

BACKGROUND: Sepsis, a life-threatening organ dysfunction caused by a dysregulated systemic immune response to infection, associates with reduced responsiveness to subsequent infections. How such tolerance is acquired is not well understood but is known to involve epigenetic and transcriptional dysre...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Genome Med
Κύριοι συγγραφείς: Lorente-Sorolla, Clara, Garcia-Gomez, Antonio, Català-Moll, Francesc, Toledano, Víctor, Ciudad, Laura, Avendaño-Ortiz, José, Maroun-Eid, Charbel, Martín-Quirós, Alejandro, Martínez-Gallo, Mónica, Ruiz-Sanmartín, Adolfo, del Campo, Álvaro García, Ferrer-Roca, Ricard, Ruiz-Rodriguez, Juan Carlos, Álvarez-Errico, Damiana, López-Collazo, Eduardo, Ballestar, Esteban
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: BioMed Central 2019
Θέματα:
Research
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6820973/
https://ncbi.nlm.nih.gov/pubmed/31665078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-019-0674-2
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