Inflammatory cytokines and organ dysfunction associate with the aberrant DNA methylome of monocytes in sepsis

BACKGROUND: Sepsis, a life-threatening organ dysfunction caused by a dysregulated systemic immune response to infection, associates with reduced responsiveness to subsequent infections. How such tolerance is acquired is not well understood but is known to involve epigenetic and transcriptional dysre...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Genome Med
Prif Awduron: Lorente-Sorolla, Clara, Garcia-Gomez, Antonio, Català-Moll, Francesc, Toledano, Víctor, Ciudad, Laura, Avendaño-Ortiz, José, Maroun-Eid, Charbel, Martín-Quirós, Alejandro, Martínez-Gallo, Mónica, Ruiz-Sanmartín, Adolfo, del Campo, Álvaro García, Ferrer-Roca, Ricard, Ruiz-Rodriguez, Juan Carlos, Álvarez-Errico, Damiana, López-Collazo, Eduardo, Ballestar, Esteban
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2019
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6820973/
https://ncbi.nlm.nih.gov/pubmed/31665078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-019-0674-2
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