Inflammatory cytokines and organ dysfunction associate with the aberrant DNA methylome of monocytes in sepsis

BACKGROUND: Sepsis, a life-threatening organ dysfunction caused by a dysregulated systemic immune response to infection, associates with reduced responsiveness to subsequent infections. How such tolerance is acquired is not well understood but is known to involve epigenetic and transcriptional dysre...

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Bibliografiska uppgifter
I publikationen:Genome Med
Huvudupphovsmän: Lorente-Sorolla, Clara, Garcia-Gomez, Antonio, Català-Moll, Francesc, Toledano, Víctor, Ciudad, Laura, Avendaño-Ortiz, José, Maroun-Eid, Charbel, Martín-Quirós, Alejandro, Martínez-Gallo, Mónica, Ruiz-Sanmartín, Adolfo, del Campo, Álvaro García, Ferrer-Roca, Ricard, Ruiz-Rodriguez, Juan Carlos, Álvarez-Errico, Damiana, López-Collazo, Eduardo, Ballestar, Esteban
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2019
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6820973/
https://ncbi.nlm.nih.gov/pubmed/31665078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-019-0674-2
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