Prostaglandin E2 Leads to the Acquisition of DNMT3A-Dependent Tolerogenic Functions in Human Myeloid-Derived Suppressor Cells

Myeloid-derived suppressor cells (MDSCs) and dendritic cells (DCs) arise from common progenitors. Tumor-derived factors redirect differentiation from immune-promoting DCs to tolerogenic MDSCs, an immunological hallmark of cancer. Indeed, in vitro differentiation of DCs from human primary monocytes r...

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Main Authors: Javier Rodríguez-Ubreva, Francesc Català-Moll, Nataša Obermajer, Damiana Álvarez-Errico, Ricardo N. Ramirez, Carlos Company, Roser Vento-Tormo, Gema Moreno-Bueno, Robert P. Edwards, Ali Mortazavi, Pawel Kalinski, Esteban Ballestar
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2017-10-01
Series:Cell Reports
Assuntos:
myeloid-derived suppressor cells
DNMT3A
epigenetics
DNA methylation
prostaglandin E2
myeloid differentiation
tolerogenesis
tolerogenic
ovarian carcinoma
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2211124717312792
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