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IL-4 orchestrates STAT6-mediated DNA demethylation leading to dendritic cell differentiation

BACKGROUND: The role of cytokines in establishing specific transcriptional programmes in innate immune cells has long been recognized. However, little is known about how these extracellular factors instruct innate immune cell epigenomes to engage specific differentiation states. Human monocytes diff...

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書目詳細資料
發表在:Genome Biol
Main Authors: Vento-Tormo, Roser, Company, Carlos, Rodríguez-Ubreva, Javier, de la Rica, Lorenzo, Urquiza, José M., Javierre, Biola M., Sabarinathan, Radhakrishnan, Luque, Ana, Esteller, Manel, Aran, Josep M., Álvarez-Errico, Damiana, Ballestar, Esteban
格式: Artigo
語言:Inglês
出版: BioMed Central 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4711003/
https://ncbi.nlm.nih.gov/pubmed/26758199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0863-2
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