IL-4 orchestrates STAT6-mediated DNA demethylation leading to dendritic cell differentiation

BACKGROUND: The role of cytokines in establishing specific transcriptional programmes in innate immune cells has long been recognized. However, little is known about how these extracellular factors instruct innate immune cell epigenomes to engage specific differentiation states. Human monocytes diff...

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Bibliografiska uppgifter
I publikationen:Genome Biol
Huvudupphovsmän: Vento-Tormo, Roser, Company, Carlos, Rodríguez-Ubreva, Javier, de la Rica, Lorenzo, Urquiza, José M., Javierre, Biola M., Sabarinathan, Radhakrishnan, Luque, Ana, Esteller, Manel, Aran, Josep M., Álvarez-Errico, Damiana, Ballestar, Esteban
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2016
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4711003/
https://ncbi.nlm.nih.gov/pubmed/26758199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0863-2
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