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IL-4 orchestrates STAT6-mediated DNA demethylation leading to dendritic cell differentiation
BACKGROUND: The role of cytokines in establishing specific transcriptional programmes in innate immune cells has long been recognized. However, little is known about how these extracellular factors instruct innate immune cell epigenomes to engage specific differentiation states. Human monocytes diff...
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發表在: | Genome Biol |
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Main Authors: | , , , , , , , , , , , |
格式: | Artigo |
語言: | Inglês |
出版: |
BioMed Central
2016
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主題: | |
在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4711003/ https://ncbi.nlm.nih.gov/pubmed/26758199 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0863-2 |
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