IL-4 orchestrates STAT6-mediated DNA demethylation leading to dendritic cell differentiation

BACKGROUND: The role of cytokines in establishing specific transcriptional programmes in innate immune cells has long been recognized. However, little is known about how these extracellular factors instruct innate immune cell epigenomes to engage specific differentiation states. Human monocytes diff...

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Veröffentlicht in:Genome Biol
Hauptverfasser: Vento-Tormo, Roser, Company, Carlos, Rodríguez-Ubreva, Javier, de la Rica, Lorenzo, Urquiza, José M., Javierre, Biola M., Sabarinathan, Radhakrishnan, Luque, Ana, Esteller, Manel, Aran, Josep M., Álvarez-Errico, Damiana, Ballestar, Esteban
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2016
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4711003/
https://ncbi.nlm.nih.gov/pubmed/26758199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0863-2
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