NF-κB-direct activation of microRNAs with repressive effects on monocyte-specific genes is critical for osteoclast differentiation

BACKGROUND: Monocyte-to-osteoclast conversion is a unique terminal differentiation process that is exacerbated in rheumatoid arthritis and bone metastasis. The mechanisms implicated in upregulating osteoclast-specific genes involve transcription factors, epigenetic regulators and microRNAs (miRNAs)....

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Publicado en:Genome Biol
Autores principales: de la Rica, Lorenzo, García-Gómez, Antonio, Comet, Natalia R, Rodríguez-Ubreva, Javier, Ciudad, Laura, Vento-Tormo, Roser, Company, Carlos, Álvarez-Errico, Damiana, García, Mireia, Gómez-Vaquero, Carmen, Ballestar, Esteban
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4290566/
https://ncbi.nlm.nih.gov/pubmed/25601191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-014-0561-5
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