Structural Basis of Colchicine-Site targeting Acylhydrazones active against Multidrug-Resistant Acute Lymphoblastic Leukemia

Tubulin is one of the best validated anti-cancer targets, but most anti-tubulin agents have unfavorable therapeutic indexes. Here, we characterized the tubulin-binding activity, the mechanism of action, and the in vivo anti-leukemia efficacy of three 3,4,5-trimethoxy-N-acylhydrazones. We show that a...

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Veröffentlicht in:iScience
Hauptverfasser: Cury, Nathália Moreno, Mühlethaler, Tobias, Laranjeira, Angelo Brunelli Albertoni, Canevarolo, Rafael Renatino, Zenatti, Priscila Pini, Lucena-Agell, Daniel, Barasoain, Isabel, Song, Chunhua, Sun, Dongxiao, Dovat, Sinisa, Yunes, Rosendo Augusto, Prota, Andrea Enrico, Steinmetz, Michel Olivier, Díaz, José Fernando, Yunes, José Andrés
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6820235/
https://ncbi.nlm.nih.gov/pubmed/31655259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.10.003
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