SB225002 Induces Cell Death and Cell Cycle Arrest in Acute Lymphoblastic Leukemia Cells through the Activation of GLIPR1

Acute Lymphoblastic Leukemia (ALL) is the most frequent childhood malignancy. In the effort to find new anti-leukemic agents, we evaluated the small drug SB225002 (N-(2-hydroxy-4-nitrophenyl)-N’-(2-bromophenyl)urea). Although initially described as a selective antagonist of CXCR2, later studies have...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: de Vasconcellos, Jaíra Ferreira, Laranjeira, Angelo Brunelli Albertoni, Leal, Paulo C., Bhasin, Manoj K., Zenatti, Priscila Pini, Nunes, Ricardo J., Yunes, Rosendo A., Nowill, Alexandre E., Libermann, Towia A., Zerbini, Luiz Fernando, Yunes, José Andrés
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547718/
https://ncbi.nlm.nih.gov/pubmed/26302043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0134783
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