SB225002 Induces Cell Death and Cell Cycle Arrest in Acute Lymphoblastic Leukemia Cells through the Activation of GLIPR1

Acute Lymphoblastic Leukemia (ALL) is the most frequent childhood malignancy. In the effort to find new anti-leukemic agents, we evaluated the small drug SB225002 (N-(2-hydroxy-4-nitrophenyl)-N’-(2-bromophenyl)urea). Although initially described as a selective antagonist of CXCR2, later studies have...

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發表在:PLoS One
Main Authors: de Vasconcellos, Jaíra Ferreira, Laranjeira, Angelo Brunelli Albertoni, Leal, Paulo C., Bhasin, Manoj K., Zenatti, Priscila Pini, Nunes, Ricardo J., Yunes, Rosendo A., Nowill, Alexandre E., Libermann, Towia A., Zerbini, Luiz Fernando, Yunes, José Andrés
格式: Artigo
語言:Inglês
出版: Public Library of Science 2015
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547718/
https://ncbi.nlm.nih.gov/pubmed/26302043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0134783
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