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Probing the Basis of α-Synuclein Aggregation by Comparing Simulations to Single-Molecule Experiments

Intrinsically disordered proteins often play an important role in protein aggregation. However, it is challenging to determine the structures and interactions that drive the early stages of aggregation because they are transient and obscured in a heterogeneous mixture of disordered states. Even comp...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biophys J
Prif Awduron: Churchill, Cassandra D.M., Healey, Mark A., Preto, Jordane, Tuszynski, Jack A., Woodside, Michael T.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Biophysical Society 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6818160/
https://ncbi.nlm.nih.gov/pubmed/31477241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2019.08.013
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