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Interplay of α-synuclein binding and conformational switching probed by single-molecule fluorescence

We studied the coupled binding and folding of α-synuclein, an intrinsically disordered protein linked with Parkinson's disease. Using single-molecule fluorescence resonance energy transfer and correlation methods, we directly probed protein membrane association, structural distributions, and dy...

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Detalhes bibliográficos
Main Authors: Ferreon, Allan Chris M., Gambin, Yann, Lemke, Edward A., Deniz, Ashok A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667048/
https://ncbi.nlm.nih.gov/pubmed/19293380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0809232106
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