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Function and dysfunction of α-Synuclein: Probing conformational changes and aggregation by single molecule fluorescence
The aggregation and deposition of the neuronal protein α-Synuclein in the substantia nigra region of the brain is a key pathological feature of Parkinson’s disease. α-Synuclein assembles from a monomeric state in solution, which lacks stable secondary and tertiary contacts, into highly structured fi...
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| Asıl Yazarlar: | , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2012
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3552099/ https://ncbi.nlm.nih.gov/pubmed/22983916 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-012-8338-x |
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