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The finger loop of the SRA domain in the E3 ligase UHRF1 is a regulator of ubiquitin targeting and is required for the maintenance of DNA methylation

The Su(var)3–9, enhancer of zeste, and trithorax (SET) and really interesting new gene (RING) finger–associated (SRA) protein domain is conserved across bacteria and eukaryota and coordinates extrahelical or “flipped” DNA bases. A functional SRA domain is required for ubiquitin-like with PHD and RIN...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Vaughan, Robert M., Rothbart, Scott B., Dickson, Bradley M.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6816099/
https://ncbi.nlm.nih.gov/pubmed/31481468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010160
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