Chromatin structure and its chemical modifications regulate the ubiquitin ligase substrate selectivity of UHRF1

Mitotic inheritance of DNA methylation patterns is facilitated by UHRF1, a DNA- and histone-binding E3 ubiquitin ligase that helps recruit the maintenance DNA methyltransferase DNMT1 to replicating chromatin. The DNA methylation maintenance function of UHRF1 is dependent on its ability to bind chrom...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Vaughan, Robert M., Dickson, Bradley M., Whelihan, Matthew F., Johnstone, Andrea L., Cornett, Evan M., Cheek, Marcus A., Ausherman, Christine A., Cowles, Martis W., Sun, Zu-Wen, Rothbart, Scott B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6126761/
https://ncbi.nlm.nih.gov/pubmed/30104358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1806373115
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