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Depletion of Mitochondrial DNA in Differentiated Retinal Pigment Epithelial Cells

We investigated the effects of treating differentiated retinal pigment epithelial (RPE) cells with didanosine (ddI), which is associated with retinopathy in individuals with HIV/AIDS. We hypothesized that such treatment would cause depletion of mitochondrial DNA and provide insight into the conseque...

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Библиографические подробности
Опубликовано в: :Sci Rep
Главные авторы: Hu, Xinqian, Calton, Melissa A., Tang, Shibo, Vollrath, Douglas
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2019
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6814719/
https://ncbi.nlm.nih.gov/pubmed/31653972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-51761-1
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