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Depletion of Mitochondrial DNA in Differentiated Retinal Pigment Epithelial Cells

We investigated the effects of treating differentiated retinal pigment epithelial (RPE) cells with didanosine (ddI), which is associated with retinopathy in individuals with HIV/AIDS. We hypothesized that such treatment would cause depletion of mitochondrial DNA and provide insight into the conseque...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Hu, Xinqian, Calton, Melissa A., Tang, Shibo, Vollrath, Douglas
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6814719/
https://ncbi.nlm.nih.gov/pubmed/31653972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-51761-1
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