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Depletion of Mitochondrial DNA in Differentiated Retinal Pigment Epithelial Cells

We investigated the effects of treating differentiated retinal pigment epithelial (RPE) cells with didanosine (ddI), which is associated with retinopathy in individuals with HIV/AIDS. We hypothesized that such treatment would cause depletion of mitochondrial DNA and provide insight into the conseque...

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Publicat a:Sci Rep
Autors principals: Hu, Xinqian, Calton, Melissa A., Tang, Shibo, Vollrath, Douglas
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6814719/
https://ncbi.nlm.nih.gov/pubmed/31653972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-51761-1
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