CXCR5(+)CD8(+) T cells are a distinct functional subset with antitumor activity

CXCR5 mediates homing of both B and follicular helper T (T(FH)) cells into follicles of secondary lymphoid organs. We found that CXCR5(+)CD8(+) T cells are present in human tonsils and follicular lymphoma, inhibit T(FH)-mediated B-cell differentiation, and exhibit strong cytotoxic activity. Consiste...

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Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Chu, Fuliang, Li, Haiyan S., Liu, Xindong, Cao, Jingjing, Ma, Wencai, Ma, Ying, Weng, Jinsheng, Zhu, Zheng, Cheng, Xiaoyun, Wang, Zhiqiang, Liu, Jingwei, Jiang, Zi Yang, Luong, Amber, Peng, Weiyi, Wang, Jing, Balakrishnan, Kumudha, Yee, Cassian, Dong, Chen, Davis, Richard Eric, Watowich, Stephanie S., Neelapu, Sattva S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6814517/
https://ncbi.nlm.nih.gov/pubmed/31028278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-019-0464-2
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