IL-15 enhances the antitumor effect of human antigen-specific CD8(+) T cells by cellular senescence delay

Optimal expansion protocols for adoptive human T-cell therapy often include interleukin (IL)-15; however, the mechanism by which IL-15 improves the in vivo antitumor effect of T cells remains to be elucidated. Using human T cells generated from HLA-A2+ donors against novel T-cell epitopes derived fr...

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Bibliographic Details
Published in:Oncoimmunology
Main Authors: Weng, Jinsheng, Moriarty, Kelsey E., Baio, Flavio Egidio, Chu, Fuliang, Kim, Sung-Doo, He, Jin, Jie, Zuliang, Xie, Xiaoping, Ma, Wencai, Qian, Jianfei, Zhang, Liang, Yang, Jing, Yi, Qing, Neelapu, Sattva S., Kwak, Larry W.
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2016
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215241/
https://ncbi.nlm.nih.gov/pubmed/28123872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1237327
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