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NSD2 overexpression drives clustered chromatin and transcriptional changes in a subset of insulated domains
CTCF and cohesin play a key role in organizing chromatin into topologically associating domain (TAD) structures. Disruption of a single CTCF binding site is sufficient to change chromosomal interactions leading to alterations in chromatin modifications and gene regulation. However, the extent to whi...
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| 出版年: | Nat Commun |
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| 主要な著者: | , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2019
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6813313/ https://ncbi.nlm.nih.gov/pubmed/31649247 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12811-4 |
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