NSD2 overexpression drives clustered chromatin and transcriptional changes in a subset of insulated domains

CTCF and cohesin play a key role in organizing chromatin into topologically associating domain (TAD) structures. Disruption of a single CTCF binding site is sufficient to change chromosomal interactions leading to alterations in chromatin modifications and gene regulation. However, the extent to whi...

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Publicado en:Nat Commun
Main Authors: Lhoumaud, Priscillia, Badri, Sana, Rodriguez-Hernaez, Javier, Sakellaropoulos, Theodore, Sethia, Gunjan, Kloetgen, Andreas, Cornwell, MacIntosh, Bhattacharyya, Sourya, Ay, Ferhat, Bonneau, Richard, Tsirigos, Aristotelis, Skok, Jane A.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6813313/
https://ncbi.nlm.nih.gov/pubmed/31649247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12811-4
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