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Stratification of TAD boundaries reveals preferential insulation of super-enhancers by strong boundaries

The metazoan genome is compartmentalized in areas of highly interacting chromatin known as topologically associating domains (TADs). TADs are demarcated by boundaries mostly conserved across cell types and even across species. However, a genome-wide characterization of TAD boundary strength in mamma...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Gong, Yixiao, Lazaris, Charalampos, Sakellaropoulos, Theodore, Lozano, Aurelie, Kambadur, Prabhanjan, Ntziachristos, Panagiotis, Aifantis, Iannis, Tsirigos, Aristotelis
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5803259/
https://ncbi.nlm.nih.gov/pubmed/29416042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03017-1
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