Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia

FTO, a mRNA N(6)-methyladenosine (m(6)A) demethylase, was reported to promote leukemogenesis. Using structure-based rational design, we have developed two promising FTO inhibitors, namely FB23 and FB23-2, which directly bind to FTO and selectively inhibit FTO’s m(6)A demethylase activity. Mimicking...

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Publicado en:Cancer Cell
Autores principales: Huang, Yue, Su, Rui, Sheng, Yue, Dong, Lei, Dong, Ze, Xu, Hongjiao, Ni, Tengfeng, Zhang, Zijie Scott, Zhang, Tao, Li, Chenying, Han, Li, Zhu, Zhenyun, Lian, Fulin, Wei, Jiangbo, Deng, Qiangqiang, Wang, Yungui, Wunderlich, Mark, Gao, Zhiwei, Pan, Guoyu, Zhong, Dafang, Zhou, Hu, Zhang, Naixia, Gan, Jianhua, Jiang, Hualiang, Mulloy, James C., Qian, Zhijian, Chen, Jianjun, Yang, Cai-Guang
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6812656/
https://ncbi.nlm.nih.gov/pubmed/30991027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.03.006
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