FTO plays an oncogenic role in acute myeloid leukemia as a N(6)-methyladenosine RNA demethylase

N(6)-methyladenosine (m(6)A) represents the most prevalent internal modification in mammalian mRNAs. Despite its functional importance in various fundamental bioprocesses, the studies of m(6)A in cancer have been limited. Here we show that FTO, as an m(6)A demethylase, plays a critical oncogenic rol...

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Publié dans:Cancer Cell
Auteurs principaux: Li, Zejuan, Weng, Hengyou, Su, Rui, Weng, Xiaocheng, Zuo, Zhixiang, Li, Chenying, Huang, Huilin, Nachtergaele, Sigrid, Dong, Lei, Hu, Chao, Qin, Xi, Tang, Lichuan, Wang, Yungui, Hong, Gia-Ming, Huang, Hao, Wang, Xiao, Chen, Ping, Gurbuxani, Sandeep, Arnovitz, Stephen, Li, Yuanyuan, Li, Shenglai, Strong, Jennifer, Neilly, Mary Beth, Larson, Richard A., Jiang, Xi, Zhang, Pumin, Jin, Jie, He, Chuan, Chen, Jianjun
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5234852/
https://ncbi.nlm.nih.gov/pubmed/28017614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.11.017
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