FTO plays an oncogenic role in acute myeloid leukemia as a N(6)-methyladenosine RNA demethylase

N(6)-methyladenosine (m(6)A) represents the most prevalent internal modification in mammalian mRNAs. Despite its functional importance in various fundamental bioprocesses, the studies of m(6)A in cancer have been limited. Here we show that FTO, as an m(6)A demethylase, plays a critical oncogenic rol...

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Gepubliceerd in:Cancer Cell
Hoofdauteurs: Li, Zejuan, Weng, Hengyou, Su, Rui, Weng, Xiaocheng, Zuo, Zhixiang, Li, Chenying, Huang, Huilin, Nachtergaele, Sigrid, Dong, Lei, Hu, Chao, Qin, Xi, Tang, Lichuan, Wang, Yungui, Hong, Gia-Ming, Huang, Hao, Wang, Xiao, Chen, Ping, Gurbuxani, Sandeep, Arnovitz, Stephen, Li, Yuanyuan, Li, Shenglai, Strong, Jennifer, Neilly, Mary Beth, Larson, Richard A., Jiang, Xi, Zhang, Pumin, Jin, Jie, He, Chuan, Chen, Jianjun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5234852/
https://ncbi.nlm.nih.gov/pubmed/28017614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.11.017
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