FTO plays an oncogenic role in acute myeloid leukemia as a N(6)-methyladenosine RNA demethylase

N(6)-methyladenosine (m(6)A) represents the most prevalent internal modification in mammalian mRNAs. Despite its functional importance in various fundamental bioprocesses, the studies of m(6)A in cancer have been limited. Here we show that FTO, as an m(6)A demethylase, plays a critical oncogenic rol...

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Publicado en:Cancer Cell
Main Authors: Li, Zejuan, Weng, Hengyou, Su, Rui, Weng, Xiaocheng, Zuo, Zhixiang, Li, Chenying, Huang, Huilin, Nachtergaele, Sigrid, Dong, Lei, Hu, Chao, Qin, Xi, Tang, Lichuan, Wang, Yungui, Hong, Gia-Ming, Huang, Hao, Wang, Xiao, Chen, Ping, Gurbuxani, Sandeep, Arnovitz, Stephen, Li, Yuanyuan, Li, Shenglai, Strong, Jennifer, Neilly, Mary Beth, Larson, Richard A., Jiang, Xi, Zhang, Pumin, Jin, Jie, He, Chuan, Chen, Jianjun
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5234852/
https://ncbi.nlm.nih.gov/pubmed/28017614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.11.017
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