Effect of Posttranslational Modifications on the Structure and Activity of FTO Demethylase

The FTO protein is involved in a wide range of physiological processes, including adipogenesis and osteogenesis. This two-domain protein belongs to the AlkB family of 2-oxoglutarate (2-OG)- and Fe(II)-dependent dioxygenases, displaying N(6)-methyladenosine (N(6)-meA) demethylase activity. The aim of...

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Publicado en:Int J Mol Sci
Main Authors: Marcinkowski, Michał, Pilžys, Tomaš, Garbicz, Damian, Piwowarski, Jan, Mielecki, Damian, Nowaczyk, Grzegorz, Taube, Michał, Gielnik, Maciej, Kozak, Maciej, Winiewska-Szajewska, Maria, Szołajska, Ewa, Dębski, Janusz, Maciejewska, Agnieszka M., Przygońska, Kaja, Ferenc, Karolina, Grzesiuk, Elżbieta, Poznański, Jarosław
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8123419/
https://ncbi.nlm.nih.gov/pubmed/33925955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22094512
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