Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia

FTO, a mRNA N(6)-methyladenosine (m(6)A) demethylase, was reported to promote leukemogenesis. Using structure-based rational design, we have developed two promising FTO inhibitors, namely FB23 and FB23-2, which directly bind to FTO and selectively inhibit FTO’s m(6)A demethylase activity. Mimicking...

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出版年:Cancer Cell
主要な著者: Huang, Yue, Su, Rui, Sheng, Yue, Dong, Lei, Dong, Ze, Xu, Hongjiao, Ni, Tengfeng, Zhang, Zijie Scott, Zhang, Tao, Li, Chenying, Han, Li, Zhu, Zhenyun, Lian, Fulin, Wei, Jiangbo, Deng, Qiangqiang, Wang, Yungui, Wunderlich, Mark, Gao, Zhiwei, Pan, Guoyu, Zhong, Dafang, Zhou, Hu, Zhang, Naixia, Gan, Jianhua, Jiang, Hualiang, Mulloy, James C., Qian, Zhijian, Chen, Jianjun, Yang, Cai-Guang
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6812656/
https://ncbi.nlm.nih.gov/pubmed/30991027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.03.006
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