載入...
Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia
FTO, a mRNA N(6)-methyladenosine (m(6)A) demethylase, was reported to promote leukemogenesis. Using structure-based rational design, we have developed two promising FTO inhibitors, namely FB23 and FB23-2, which directly bind to FTO and selectively inhibit FTO’s m(6)A demethylase activity. Mimicking...
Na minha lista:
| 發表在: | Cancer Cell |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2019
|
| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6812656/ https://ncbi.nlm.nih.gov/pubmed/30991027 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.03.006 |
| 標簽: |
添加標簽
沒有標簽, 成為第一個標記此記錄!
|