MTAP loss promotes stemness in glioblastoma and confers unique susceptibility to purine starvation

Homozygous deletion of methylthioadenosine phosphorylase (MTAP) is one of the most frequent genetic alterations in glioblastoma (GBM), but its pathologic consequences remain unclear. In this study, we report that loss of MTAP results in profound epigenetic reprogramming characterized by hypomethylat...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cancer Res
Hauptverfasser: Hansen, Landon J., Sun, Ran, Yang, Rui, Singh, Simranjit X., Chen, Lee H., Pirozzi, Christopher J., Moure, Casey J., Hemphill, Carlee, Carpenter, Austin B., Healy, Patrick, Ruger, Ryan C., Chen, Chin-Pu J., Greer, Paula K., Zhao, Fangping, Spasojevic, Ivan, Grenier, Carole, Huang, Zhiqing, Murphy, Susan K., McLendon, Roger E., Friedman, Henry S., Friedman, Allan H., Herndon, James E., Sampson, John H., Keir, Stephen T., Bigner, Darell D., Yan, Hai, He, Yiping
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6810595/
https://ncbi.nlm.nih.gov/pubmed/31040154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-1010
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge