MGMT: Immunohistochemical Detection in High-Grade Astrocytomas

Glioma therapeutic resistance to alkylating chemotherapy is mediated via O6-methylguanine-DNA methyltransferase (MGMT). We hypothesized that a CD45/HAM56/MGMT double-stained cocktail would improve MGMT discrimination in tumor cells versus inflammatory and endothelial cells (IEC). Total MGMT protein...

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Detalhes bibliográficos
Publicado no:J Neuropathol Exp Neurol
Main Authors: Lipp, Eric S, Healy, Patrick, Austin, Alan, Clark, Alysha, Dalton, Tara, Perkinson, Kathryn, Herndon, James E, Friedman, Henry S, Friedman, Allan H, Bigner, Darell D, McLendon, Roger E
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7967844/
https://ncbi.nlm.nih.gov/pubmed/30500933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnen/nly110
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