MTAP loss promotes stemness in glioblastoma and confers unique susceptibility to purine starvation

Homozygous deletion of methylthioadenosine phosphorylase (MTAP) is one of the most frequent genetic alterations in glioblastoma (GBM), but its pathologic consequences remain unclear. In this study, we report that loss of MTAP results in profound epigenetic reprogramming characterized by hypomethylat...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Hansen, Landon J., Sun, Ran, Yang, Rui, Singh, Simranjit X., Chen, Lee H., Pirozzi, Christopher J., Moure, Casey J., Hemphill, Carlee, Carpenter, Austin B., Healy, Patrick, Ruger, Ryan C., Chen, Chin-Pu J., Greer, Paula K., Zhao, Fangping, Spasojevic, Ivan, Grenier, Carole, Huang, Zhiqing, Murphy, Susan K., McLendon, Roger E., Friedman, Henry S., Friedman, Allan H., Herndon, James E., Sampson, John H., Keir, Stephen T., Bigner, Darell D., Yan, Hai, He, Yiping
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6810595/
https://ncbi.nlm.nih.gov/pubmed/31040154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-1010
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