1550. PK-PD Relationship and PK Driver of Efficacy of the Novel Antibacterial Lysin Exebacase (CF-301) in Pre-Clinical Models

BACKGROUND: Exebacase (CF-301) is a novel lysin with rapid bacteriolytic and anti-biofilm activity against S. aureus, pronounced synergy with antibiotics and low propensity for resistance. Exebacase has undergone Phase 1–2 trials. This work was to develop pharmacokinetic (PK) model in animal and det...

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Veröffentlicht in:Open Forum Infect Dis
Hauptverfasser: Ghahramani, Parviz, Chiu, Joannellyn, Asempa, Tomefa E, Abdelraouf, Kamilia, Nicolau, David P, Abdel Hady, Wessam, Xiong, Yan, Bayer, Arnold, Carabeo, Teresa, Cassino, Cara, Schuch, Raymond, Lehoux, Dario
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6810366/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofz360.1414
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