671. Impact of Dose-Administration Strategies of the Antistaphylococcal Lysin Exebacase, (CF-301), in Addition to Daptomycin (DAP) in an Experimental Infective Endocarditis (IE) Model due to Methicillin-Resistant Staphylococcus aureus (MRSA)

BACKGROUND: MRSA infections, especially involving the endovascular system (e.g., IE), are associated with unacceptably high morbidity and mortality rates. The use of bacteriophage-derived lysin, which acts as direct lytic agents, represents a novel adjunctive approach against virulent Gram-positive...

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Publicado en:Open Forum Infect Dis
Autores principales: Xiong, Yan, Abdelhady, Wessam, Li, Liang, Schuch, Raymond, Cassino, Cara, Lehoux, Dario, Bayer, Arnold
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2019
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Abstracts
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6811205/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofz360.739
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