1550. PK-PD Relationship and PK Driver of Efficacy of the Novel Antibacterial Lysin Exebacase (CF-301) in Pre-Clinical Models

BACKGROUND: Exebacase (CF-301) is a novel lysin with rapid bacteriolytic and anti-biofilm activity against S. aureus, pronounced synergy with antibiotics and low propensity for resistance. Exebacase has undergone Phase 1–2 trials. This work was to develop pharmacokinetic (PK) model in animal and det...

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Bibliografski detalji
Izdano u:Open Forum Infect Dis
Glavni autori: Ghahramani, Parviz, Chiu, Joannellyn, Asempa, Tomefa E, Abdelraouf, Kamilia, Nicolau, David P, Abdel Hady, Wessam, Xiong, Yan, Bayer, Arnold, Carabeo, Teresa, Cassino, Cara, Schuch, Raymond, Lehoux, Dario
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2019
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Abstracts
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6810366/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofz360.1414
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