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Activation of Sigma 1 Receptor Extends Survival of Cones and Improves Visual Acuity in a Murine Model of Retinitis Pigmentosa

PURPOSE: Retinitis pigmentosa (RP), a retinal photoreceptor degeneration, typically affects rod function and subsequently cones. Activation of sigma 1 receptor (Sig1R) has been shown to preserve cone function through 6 weeks in the rd10 mouse model of RP, when mice were treated systemically with the...

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Publicado en:Invest Ophthalmol Vis Sci
Main Authors: Wang, Jing, Saul, Alan, Smith, Sylvia B.
Formato: Artigo
Idioma:Inglês
Publicado: The Association for Research in Vision and Ophthalmology 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6808049/
https://ncbi.nlm.nih.gov/pubmed/31639826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.19-27709
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