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Comparison of Neuroprotective Effects of Monomethylfumarate to the Sigma 1 Receptor Ligand (+)-Pentazocine in a Murine Model of Retinitis Pigmentosa

PURPOSE: Activating the cell survival modulator sigma 1 receptor (Sig1R) delays cone photoreceptor cell loss in Pde6βrd10/J (rd10) mice, a model of retinitis pigmentosa. Beneficial effects are abrogated in rd10 mice lacking NRF2, implicating NRF2 as essential to Sig1R-mediated cone neuroprotection....

詳細記述

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書誌詳細
出版年:Invest Ophthalmol Vis Sci
主要な著者: Xiao, Haiyan, Wang, Jing, Saul, Alan, Smith, Sylvia B.
フォーマット: Artigo
言語:Inglês
出版事項: The Association for Research in Vision and Ophthalmology 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7401726/
https://ncbi.nlm.nih.gov/pubmed/32150247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.61.3.5
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