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Activation of the molecular chaperone, sigma 1 receptor, preserves cone function in a murine model of inherited retinal degeneration

Retinal degenerative diseases are major causes of untreatable blindness, and novel approaches to treatment are being sought actively. Here we explored the activation of a unique protein, sigma 1 receptor (Sig1R), in the treatment of PRC loss because of its multifaceted role in cellular survival. We...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Wang, Jing, Saul, Alan, Roon, Penny, Smith, Sylvia B.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4932934/
https://ncbi.nlm.nih.gov/pubmed/27298364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1521749113
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