Role of the sigma-1 receptor chaperone in rod and cone photoreceptor degenerations in a mouse model of retinitis pigmentosa

BACKGROUND: Retinitis pigmentosa (RP) is the most common inherited retinal degenerative disease yet with no effective treatment available. The sigma-1 receptor (S1R), a ligand-regulated chaperone, emerges as a potential retina-protective therapeutic target. In particular, pharmacological activation...

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Vydáno v:Mol Neurodegener
Hlavní autoři: Yang, Huan, Fu, Yingmei, Liu, Xinying, Shahi, Pawan K., Mavlyutov, Timur A., Li, Jun, Yao, Annie, Guo, Steven Z.-W., Pattnaik, Bikash R., Guo, Lian-Wang
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2017
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5606113/
https://ncbi.nlm.nih.gov/pubmed/28927431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-017-0202-z
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