Photoreceptor protection via blockade of BET epigenetic readers in a murine model of inherited retinal degeneration

BACKGROUND: The bromodomain and extraterminal domain (BET) family proteins (BET2, BET3, and BET4) “read” (bind) histone acetylation marks via two distinct bromodomains (Brom1 and Brom2) facilitating transcriptional activation. These epigenetic “readers” play crucial roles in pathogenic processes suc...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Zhao, Lei, Li, Jun, Fu, Yingmei, Zhang, Mengxue, Wang, Bowen, Ouellette, Jonathan, Shahi, Pawan K., Pattnaik, Bikash R., Watters, Jyoti J., Wong, Wai T., Guo, Lian-Wang
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5248448/
https://ncbi.nlm.nih.gov/pubmed/28103888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0775-4
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