Photoreceptor protection via blockade of BET epigenetic readers in a murine model of inherited retinal degeneration

BACKGROUND: The bromodomain and extraterminal domain (BET) family proteins (BET2, BET3, and BET4) “read” (bind) histone acetylation marks via two distinct bromodomains (Brom1 and Brom2) facilitating transcriptional activation. These epigenetic “readers” play crucial roles in pathogenic processes suc...

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Publicado en:J Neuroinflammation
Autores principales: Zhao, Lei, Li, Jun, Fu, Yingmei, Zhang, Mengxue, Wang, Bowen, Ouellette, Jonathan, Shahi, Pawan K., Pattnaik, Bikash R., Watters, Jyoti J., Wong, Wai T., Guo, Lian-Wang
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5248448/
https://ncbi.nlm.nih.gov/pubmed/28103888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0775-4
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