BET Bromodomain Blockade Mitigates Intimal Hyperplasia in Rat Carotid Arteries

BACKGROUND: Intimal hyperplasia is a common cause of many vasculopathies. There has been a recent surge of interest in the bromo and extra-terminal (BET) epigenetic “readers” including BRD4 since the serendipitous discovery of JQ1(+), an inhibitor specific to the seemingly undruggable BET bromodomai...

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Publicado en:EBioMedicine
Autores principales: Wang, Bowen, Zhang, Mengxue, Takayama, Toshio, Shi, Xudong, Roenneburg, Drew Alan, Craig Kent, K., Guo, Lian-Wang
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2015
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4740308/
https://ncbi.nlm.nih.gov/pubmed/26870791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2015.09.045
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